Our Interests
Our lab focuses on organismic interactions of microbe-microbe and microbe-higher eukaryotes (e.g. humans, plants, insects, and nematodes) in Nature’s battlefield
- Driven by “big data + multi-omics”, revealing the secrets of small molecule-mediated organismic interactions. (Exploration)
- Empowered by synthetic biology, chemical ecology facilitates the discovery and modification of drug lead compounds. (Application)
我们专注于大自然“战场”中的微生物-微生物以及微生物-高等真核生物（人类、植物、昆虫、线虫）的相互作用
- 以大数据与多组学为驱动，解析小分子介导的微生物生命过程 （格物致知）
- 以合成生物学赋能化学生态学，加速先导化合物的发现与定向改造 （格物致用）
Recent Publications
(*corresponding author, #equal contributions)
1. Lena Peters#, Moritz Drechsler#, Barbara Pees, Georgia Angelidou, Liesa Salzer, Karlis Arturs Moors, Nicole Paczia, Hinrich Schulenburg, Yi-Ming Shi, Christoph Kaleta, Michael Witting, Helge B. Bode*, Katja Dierking*
Polyketide synthase-derived sphingolipids determine microbiota-mediated protection against pathogens in C. elegans.
Nat. Commun. 2025, 16, 5151.
Press release: New insights into microbiome-mediated protection against pathogens
2. Juliana Effert#; Margaretha Westphalen#; Andrea Calderari#; Yi-Ming Shi; Isam Elamri; Soumaya Najah; Peter Grün; Yanyan Li; Arnaud Gruez; Kira J. Weissman*; Helge B Bode*
Pyrrolizwilline, a unique bacterial alkaloid assembled by a nonribosomal peptide synthetase and non-enzymatic dimerization
Angew. Chem. 2024, 63, e202411258.
3. Yuyang Wang; Yan-Ni Shi; Hao Xiang; Yi-Ming Shi*
Exploring nature’s battlefield: organismic interactions in the discovery of bioactive natural products.
Nat. Prod. Rep. 2024, 41, 1630-1651. (Cover Article)
Press release: SIAT, biotrade | 生物通, ScienceNet | 科学网, Sina | 新浪
4. Zhao Xia#; Hao Xiang#; Yi-Ming Shi*
Bacterial secondary metabolites embedded in producer cell membranes and antibiotics targeting their biosynthesis.
ChemMedChem 2024, 19, e202400469.
5. Jing, S.-X.; Fu, R.; Li, C.-H.; Hugelshofer, C. L.; Shi, Y.-M.; Luo, S.-H.; Liu, Y.-C.; Liu, Y.; Li, S.-H.*
Discovery of Unusual Sesterterpenoids from Colquhounia coccinea var. mollis and Their Metabolic Implications.
J. Nat. Prod. 2023, 86, 2468-2473.
6. Meesil, W.; Muangpat, P.; Sitthisak, S.; Rattanarojpong, T.; Chantratita, N.; Machado, R. A. R.; Shi, Y.-M.; Bode, H. B.; Vitta, A.; Thanwisai, A.*
Genome mining reveals novel biosynthetic gene clusters in entomopathogenic bacteria.
Sci. Rep. 2023, 13, 20764.
7. Zolfaghariyan, S.; Shakeri, A.; Asili, J.; Tarighi, S.; Grün, P.; Shi, Y.-M.; Bode, H. B.; Karimi, J.*
Cyclic Depsipeptides and Linear Peptides With Cytotoxic and Antiphytopathogenic Activities From Symbiotic Bacteria of Xenorhabdus (Enterobacteriales: Morganellaceae) Genus.
Ann. Entomol. Soc. Am. 2023, 116, 114-124.
8. Shi, Y.-M.*; Hirschmann, M.; Shi, Y.-N.; Ahmed, S; Abebew, D.; Tobias, N. J.; Grün, P.; Crames, J. J.; Pöschel, L.; Kuttenlochner, W.; Richter, C.; Herrmann, J.; Müller, R; Thanwisai, A; Pidot, S. J.; Stinear, T. P.; Groll, M; Kim, Y.; Bode, H. B.*
Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.
Nat. Chem. 2022, 14, 701-712.
Press release: Finding new weapons in Nature’s battlesites
9. Shi, Y.-M.*#; Crames, J. J.#; Czech, L.; Bozhüyük, K. A. J.; Shi, Y.-N.; Hirschmann, M.; Lamberth, S.; Paczia, N.; Rückert, C.; Kalinowski, J.; Bange, G.; Bode, H. B.*
Genome mining enabled by biosynthetic characterization uncovers a widespread class of benzoxazolinate-containing natural products.
Angew. Chem. Int. Ed. 2022, 61, e202206106.
Press release: Revealing Biochemical “Rings of Power”
10. Shi, Y.-M.*; Hirschmann, M.; Shi, Y.-N.; Bode, H. B.*
Cleavage off-loading and post-assembly-line conversions yield products with unusual termini during biosynthesis.
ACS Chem. Biol. 2022, 17, 2221-2228.
SyM Lab 